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Title: The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry
Authors: Pierucci, Massimo
Di Matteo, Vincenzo
Benigno, Arcangelo
Crescimanno, Giuseppe
Esposito, Ennio
Di Giovanni, Giuseppe
Keywords: Parkinson's disease
Rats as laboratory animals
Chromatography, High pressure liquid
Brain stem
Cerebral cortex
Hippocampus (Brain)
Issue Date: 2009
Publisher: Wiley-Blackwell Publishing, Inc.
Citation: Pierucci, M., Di Matteo, V., Beningo, A., Crescimanno, G., Esposito, E., & Di Giovanni, G. (2009). The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry. Annals of the New York Academy of Sciences, 1155, 316-323.
Abstract: 6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined: the brain stem, cerebellum, hippocampus, striatum, and cortex. 6-OHDA-unilateral lesion dramatically modified DA, serotonin (5-HT) and their metabolites contents in both sides of the different brain nuclei. Furthermore, unilateral 6-OHDA lesion reduced DA and 5-HT contents and produced a robust inversion of their turnover in the nonlesioned side compared to sham-operated rats. These data suggest that 6-OHDA unilateral nigral lesion produces bilateral monoamine level modifications, and this piece of evidence should be taken into account when one interprets data from animal models of unilateral PD.
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