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Title: Physicochemical parameters as a predictive tool for optimum dispersion of active pharmaceutical ingredients
Authors: Ellul, Maria
Sinagra, Emmanuel
Farrugia, Claude
Keywords: Drugs -- Analysis
Pharmaceutical technology
Issue Date: 2012
Publisher: University of Malta. Department of Chemistry
Citation: Ellul, M., Sinagra, E., & Farrugia, C. (2012). Physicochemical parameters as a predictive tool for optimum dispersion of active pharmaceutical ingredients. Seventh National Chemistry Symposium, Department of Chemistry, University of Malta, Malta.
Abstract: Particle size analysis of active pharmaceutical ingredients (API) using wet dispersion is by far the most widespread method in the pharmaceutical industry. However, despite this being a well-established procedure, there are still no hard-and-fast rules which give an indication of which dispersing conditions may be most effective at dispersing the API particles prior to their application. Usually, the analyst takes a system specific approach, and tries a number of different dispersing liquid and surfactant combinations until the desired degree of dispersion is achieved. This study addressed the possibility of constructing a predictive model that may give an indication as to the effectiveness of a specific set of dispersion conditions prior to their application, particularly for dispersions in hydrophobic media.
Appears in Collections:Scholarly Works - FacSciChe
Scholarly Works - JCChe

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