• Revisiting the Betti synthesis : using a cheap, readily-available, recyclable clay catalyst in solventless conditions 

  Bosica, Giovanna; Abdilla, Roderick; Demanuele, Kaylie (Wiley - V C H Verlag GmbH & Co. KGaA, 2018)

  One‐pot multicomponent reactions have gained significant importance in recent years because they are usually more selective, simple, efficient, atom‐economic and green than their multistep counterparts. The Betti synthesis ...
• One-Pot Aza-Friedel–Crafts reaction on amberlyst 15-supported silicotungstic acid 

  Bosica, Giovanna; Abdilla, R. (Thieme Stuttgart, 2017)

  In the aza-Friedel–Crafts reaction of 3,4-dichlorobenzaldehyde, indole, and N-methylaniline, the catalyst was recovered by filtration and reused four times with slight loss of its catalytic activity (fourth run; 99% ...
• One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions 

  Bosica, Giovanna; Zammit, Ramon (PeerJ Inc., 2018)

  An environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of β-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly ...
• Optimisation of fluorapatite coating synthesis applied to a biodegradable substrate 

  Caligari Conti, Malcolm; Xerria, Gianella; Peyrouzeta, Florian; Schembri Wismayer, Pierre; Sinagra, Emmanuel; Mantovani, Diego; Vella, Daniel; Buhagiar, Joseph (Taylor and Francis Ltd., 2018)

  Fluorapatite was synthesised using the sol–gel route at three different pH values and aged for a number of days. The coating that was determined to be of optimal morphology was then applied to a pure iron substrate and to ...
• Stents with Zero Poisson's ratio cells 

  Grima, Joseph N.; Casha, Aaron; Gatt, Ruben (2011)

  Various stents comprising cells having substantially zero Poisson's ratio are disclosed. According to a disclosed embodiment, there is provided a stent, comprising: a tubular frame formed from a non-woven network of open ...
• Isolute®Si-carbonate catalyzes the nitronate addition to both aldehydes and electron-poor alkenes under solvent-free conditions 

  Ballini, Roberto; Bosica, Giovanna; Palmieri, Alessandro; Pizzo, Ferdinando; Vaccaro, Luigi (The Royal Society of Chemistry, 2008)

  It has been found that commercial ISOLUTE® Si-carbonate catalyzes both nitroaldol and Michael reactions, from nitroalkanes and under solvent-free conditions, allowing satisfactory to good yields of nitroalkanols and ...
• A new two-step synthesis of 2-alkylated 1, 4-diketones and α-alkylated γ-keto esters 

  Ballini, Roberto; Bosica, Giovanna; Petrelli, Lara; Petrini, Marino (Thieme Stuttgart, 1999)

  2-Alkylated 1,4-diketones and a-alkylated g-keto esters can be easily prepared by a two-step procedure which involves first the conjugate addition of a nitroalkane to an enedione derivative in acetonitrile with DBU as ...
• Solvent free synthesis and deprotection of 1, 1-diacetates over a commercially available zeolite Y as a reusable catalyst 

  Ballini, Roberto; Bordoni, Marco; Bosica, Giovanna (Elsevier Science Ltd., 1998)

  Chemoselective synthesis and deprotection of 1, l-diacetates have been performed in good yields and in the absence of any solvent by zeolite HSZ-360 as a new reusable catalyst.
• Zeolite HSZ-360 as a new reusable catalyst for the direct acetylation of alcohols and phenols under solventless conditions 

  Ballini, Roberto; Bosica, Giovanna; Carloni, Silvia; Ciaralli, Lara; Maggi, Raimondo; Sartori, Giovanni (Elsevier Science Ltd., 1998)

  Alcohols and phenols were efficiently acylated with acetic anhydride without solvent over zeolite HSZ-360. The catalyst can be reused with no activity loss.
• A new 1, 4-elimination of benzenesulfinic acid from β-keto phenylsulphones via their tosylhydrazones 

  Ballini, Roberto; Bosica, Giovanna; Marcantoni, Enrico (Elsevier Science Ltd., 1996)

  Reaction of β-keto phenylsulphone tosylhydrazones 2 with 2 eq. of DBU, at r.t. in dichloromethane, affords α,β-unsaturated ketone tosylhydrazones 4, via the tosylazoalkenes 3 obtained by 1,4-elimination of benzenesulfinic acid.
• A new, one pot synthesis of alkylated methyl tri- and tetracarboxylate derivatives by nitrolkanes 

  Ballini, Roberto; Bosica, Giovanna; Fiorini, Dennis; Gil, Maria Victoria; Palmieri, Alessandro (Georg Thieme Verlag Stuttgart, 2004)

  The reaction of nitroalkanes with trimethyl trans-aconitate in acetonitrile, in the presence of DBU as base, allows the one pot formation of alkylated methyl tri- and tetralkanoate derivatives via base induced nitrous acid ...
• A regioselective one-pot Aza-Friedel-Crafts reaction for primary, secondary and tertiary anilines using a heterogeneous catalyst 

  Bosica, Giovanna; Abdilla, Roderick (The Royal Society of Chemistry, 2017)

  A one-pot multicomponent aza-Friedel-Crafts reaction was performed under green, neat and heterogeneous conditions in the presence of 1.25 mmol% of 30% w/w silicotungstic acid supported on Amberlyst 15 beads. In a yet ...
• Solvent-free Henry and Michael reactions with nitroalkanes promoted by potassium carbonate as a versatile heterogeneous catalyst 

  Bosica, Giovanna; Polidano, Kurt (Hindawi Limited, 2017)

  The use of a simple weak inorganic base such as potassium carbonate facilitated the formation of carbon-carbon bonds through both the Henry and the Michael reactions with nitrocompounds. The application of this catalyst ...
• 2,5-dialkylfurans and nitroalkanes as source of 2,3,5-trialkylpyrroles 

  Ballini, Roberto; Barboni, Luciano; Bosica, Giovanna; Petrini, Marino (Thieme Stuttgart, 2000)

  The synthesis of 2,3,5-trialkylpyrroles can be easily achieved by conjugate addition of nitroalkanes to 2-alken-1,4-dione (prepared by oxidative cleavage of 2,5-dialkylfuran) in acetonitrile with DBU as base, followed by ...
• Physiological rules for the heart, lungs and other pressure-based organs 

  Casha, Aaron; Camilleri, Liberato; Manche, Alexander; Gatt, Ruben; Gauci, Marilyn; Camilleri-Podesta, Marie-Therese; Grima, Joseph N.; Scarci, Marco; Chetcuti, Stanley (Pioneer Bioscience Publishing Company, 2017)

  Background: The adherence of the heart to physical laws, such as Laplace’s Law, may act as a measure of the organ’s relative efficiency. Allometric relationships were investigated to assess the heart’s efficiency concerning ...
• Natural architectural design 

  Grima, Joseph N.; Casha, Aaron; Rybicki, Jaroslaw (University of Malta, 2015)

  Science, engineering and medicine are three rather distinct disciplines. However, encounters between researchers in these fields often result in dialogues and exchanges on how their different worlds are not that dissimilar. ...
• Problemi ambjentali tal-gejjieni 

  Vella, Alfred J. (Sensiela Kotba Socjalisti, 1995)

  M'hemmx għalfejn globu tal-ħġieġ biex jgħinek tbassar li fost il-problemi li se jkollna niffaċċjaw fil-bidu tas-Seklu l-ġdid se jkun hemm dawk li jikkonċernaw l-użu tar-riżorsi, inkluż ir-riżors ambjentali. Mhux talli ...
• 6th Annual Science in the House exhibition 

  Magri, David C. (Malta Chamber of Scientists, 2017-12)

  The Science in the House media exhibition was held on Friday 29th September 2017 at 5:00 pm in the main foyer of the Parliament Building in Valletta. The event opened with a personal brief welcome followed by an opening ...
• A simple, efficient, two-step synthesis of symmetric 2,7-dialkyl-1,6-dioxaspiro[4.4]nonanes 

  Ballini, Roberto; Bosica, Giovanna; Uselli, Alessandra (Wiley-Blackwell Publishing, Inc., 1994)

  A two-step synthesis of symmetric 2,7-dialkyl-1,6-dioxaspiro[4.4]nonanes has been achieved by double Michael addition of nitromethane with two moles of enones on Amberlyst A21, followed by in situ reduction with sodium ...
• Nitroalkanes and dimethyl maleate as source of 3-alkyl succinic anhydrides and (E)-3-alkylidene succinic anhydrides 

  Ballini, Roberto; Bosica, Giovanna; Fiorini, Dennis; Righi, Paolo (Georg Thieme Verlag, 2002)

  Nitroalkanes react with dimethyl maleate giving a tandem Michael addition/elimination of nitrous acid. The obtained (E)-2-alkylidene dimethyl succinates are: (i) reduced to the corresponding 2-alkyl dimethyl succinates ...

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