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Title: The effect of particle size on the intrinsic dissolution of acetylsalicylic acid
Authors: Darmanin, Kristina
Frey, Hans Helmut
Farrugia, Claude
Keywords: Aspirin -- Toxicology
Issue Date: 2011
Publisher: University of Malta. Department of Chemistry
Citation: Darmanin, K., Frey, H. H., & Farrugia, C. (2011) The effect of particle size on the intrinsic dissolution of acetylsalicylic acid. Sixth National Chemistry Symposium, Department of Chemistry, University of Malta.
Abstract: Dissolution has an important role in the release of active ingredients from pharmaceutical preparations. The main focus of dissolution testing is in the area of quality control and product development, since the test yields information related to the composition and manufacturing variables. Moreover, the rate of dissolution is studied during the course of a new chemical entity development since it predicts potential bioavailability. The research objective of this study was to examine the dissolution rate of acetylsalicylic acid nondisintegrating compacts made up from four different particle sizes while exposing only a fixed surface area to the dissolution medium. This is also known as the rate of intrinsic dissolution, which is regarded as a characterization study and is therefore not referenced in individual monographs.
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