Please use this identifier to cite or link to this item:
Title: Cholinergic pathways and cognition in patients with schizophrenia : a pilot study
Authors: Rajji, Tarek K.
Chow, Tiffany W.
Voineskos, Aristotle N.
Links, Kira A.
Miranda, Dielle
Mamo, David
Ismail, Zahinoor
Pollock, Bruce G.
Mulsant, Benoit H.
Keywords: Parasympathomimetic agents
Cognition -- Data processing
Issue Date: 2012
Publisher: Elsevier BV
Citation: Rajji, T. K., Chow, T. W., Voineskos, A. N., Links, K. A., Miranda, D., Mamo, D. C., ... & Mulsant, B. H. (2012). Cholinergic pathways and cognition in patients with schizophrenia: a pilot study. Schizophrenia Research, 139(1), 46-52.
Abstract: Background: Cognitive deficits are core features in schizophrenia. Disruption in cholinergic neurotransmission has been associated with executive dysfunction in animals and humans. The objective of this study was to eval- uate the impact of compromised cholinergic pathways on executive versus non-executive cognitive functions of patients with schizophrenia. Methods: 62 patients with schizophrenia and 62 age- and sex-matched non-psychiatric control subjects (“controls”) were assessed and compared using: clinical measures, cognitive measures of global cognition, executive func- tion, and memory; and an MRI-based visual rating scale that assesses damage strategically localized within the cholinergic pathways. Results: 11 of the 62 patients with schizophrenia (17.7%) and 6 of the 62 controls (9.7%) had compromised cho- linergic pathways. These proportions were not statistically significant. Patients and controls with compromised cholinergic pathways were more impaired on measures related to executive function than patients or controls without compromised pathways. Conclusions: Patients with schizophrenia have worse executive function than controls. Compromised choliner- gic pathways appear to worsen the executive dysfunction observed in schizophrenia. If these preliminary find- ings are replicated, they could lead to the identification of a subgroup of patients with schizophrenia who could specifically benefit from interventions enhancing cholinergic neurotransmission.
Appears in Collections:Scholarly Works - FacM&SPsy

Files in This Item:
File Description SizeFormat 
  Restricted Access
525.36 kBAdobe PDFView/Open Request a copy

Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.