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Title: | Unprecedented one-pot multicomponent synthesis of propargylamines using Amberlyst A-21 supported CuI under solvent-free conditions |
Authors: | Bosica, Giovanna Gabarretta, John |
Keywords: | Asymmetric synthesis Solvent wastes |
Issue Date: | 2015 |
Publisher: | Royal Society of Chemistry |
Citation: | Bosica, G., & Gabarretta, J. (2015). Unprecedented one-pot multicomponent synthesis of propargylamines using Amberlyst A-21 supported CuI under solvent-free conditions. RSC Advances, 57(5), 46074-46087. |
Abstract: | Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component reaction between amines, aldehydes and alkynes, commonly called A3-coupling. An environmentally benign, one-pot, A3-coupling reaction of various aldehydes, amines and terminal alkynes for the synthesis of propargylamine derivatives is here described. The developed protocol avoids the use of solvent and produces a variety of propargylamines in excellent yields within short reaction times. The catalyst can be easily prepared, recovered and reused for several times, without any appreciable loss in its activity. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/24881 |
Appears in Collections: | Scholarly Works - FacSciChe |
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