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https://www.um.edu.mt/library/oar/handle/123456789/24887| Title: | A new synthesis of exo-methylene butyrolactones from nitroalkanes |
| Authors: | Ballini, Roberto Bosica, Giovanna Livi, Damiana |
| Keywords: | Nitro compounds -- Synthesis Lactones Chemical reactions |
| Issue Date: | 2001 |
| Publisher: | Georg Thieme Verlag |
| Citation: | Ballini, R., Bosica, G., & Livi, D. (2001). A new synthesis of exo-methylene butyrolactones from nitroalkanes. Synthesis, 10, 1519-1522. |
| Abstract: | A versatile route to exo-methylene butyrolactones was developed by employing a three step reaction sequence consisting of Michael addition of primary nitroalkanes 1 to ethyl (2-bromomethyl)acrylate (2), then Nef conversion of the nitro derivatives 3, and subsequent lactonization of the obtained keto esters 4. The method is chemoselective for important functionalities such as ester, C=C double bond and hydroxyl. |
| URI: | https://www.um.edu.mt/library/oar//handle/123456789/24887 |
| Appears in Collections: | Scholarly Works - FacSciChe |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ballini2001.pdf Restricted Access | 56.48 kB | Adobe PDF | View/Open Request a copy |
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