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Title: The biomarker-based diagnosis of Alzheimer’s disease. Ethical and societal issues
Other Titles: The biomarker-based diagnosis of Alzheimer’s disease. 1-ethical and societal issues
Authors: Porteri, Corinna
Albanese, Emiliano
Scerri, Charles
Carrillo, Maria C.
Snyder, Heather M.
Martensson, Birgitta
Baker, Mark
Giacobini, Ezio
Boccardi, Marina
Winblad, Bengt
Frisoni, Giovanni B.
Hurst, Samia
Geneva Task Force for the Roadmap of Alzheimer’s Biomarkers
Keywords: Alzheimer's disease
Mild cognitive impairment
Informed consent (Medical law)
Disclosure of information
Genetics -- Moral and ethical aspects
Issue Date: 2017
Publisher: Elsevier Inc.
Citation: Porteri, C., Albanese, E., Scerri, C., Carrillo, M. C., Snyder, H. M., Martensson, B.,… Hurst, S. (2017). The biomarker-based diagnosis of Alzheimer’s disease. 1-ethical and societal issues. Neurobiology of Aging, 52, 132-140.
Abstract: There is great interest in the use of biomarkers to assist in the timely identification of Alzheimer's disease (AD) in individuals with mild symptoms. However, the inclusion of AD biomarkers in clinical criteria poses socioethical challenges. The Geneva Task Force for the Roadmap of Alzheimer's Biomarkers was established to deliver a systematic strategic research agenda (aka roadmap) to promote efficient and effective validation of AD biomarkers and to foster their uptake in clinical practice. In this article, we summarize the workshop discussion of the Geneva Task Force “ethical and societal issues” working group, which comprised bioethicists, clinicians, health economists, and representatives of those affected by AD. The working group identified the following key issues that need to be included in the roadmap: improving access to services through timely diagnosis, the need for a diagnostic research protocol before moving to clinical routine, recruitment in diagnostic research protocols in the absence of effective therapy, respect for the autonomy of the individual with mild cognitive impairment in information and consent process and the right not to know biomarkers results, need for counseling programs, disclosure of the diagnosis in a structured environment and the involvement of family members, health policies including the individuals' views and the protection of their interests, and the economic costs for society.
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