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Title: | Characterization and locus assignment of two α-globin variants present in the Maltese population : Hb St. Luke's [α95 (G2) Pro→ Arg] and Hb Setif [α94 (G1) Asp→ Tyr] |
Authors: | Bezzina Wettinger, Stephanie Galdies, Ruth Scerri, Christian A. Felice, Alex |
Keywords: | Human genetics -- Variation Thalassemia Hemoglobin polymorphisims -- Malta |
Issue Date: | 1999 |
Publisher: | Taylor & Francis |
Citation: | Bezzina Wettinger, S., Galdies, R., Scerri, C., & Felice, A. E. (1999). Characterization and locus assignment of two α-globin variants present in the Maltese population: Hb St. Luke's [α95 (G2) Pro→ Arg] and Hb Setif [α94 (G1) Asp→ Tyr]. Hemoglobin, 23(2), 145-157. |
Abstract: | Two types of α-globin variants were found in 0.2% of a large number of newborn from Malta. The two hemoglobins were identified from tryptic maps on a Vydac C18 column and by α-globin gene sequencing as Hb St. Luke's (isoelectric point = 7.18 ± 0.017) and Hb Setif (isoelectric point = 7.26 ± 0.010). Hb St. Luke's [α95(G2)Pro→Arg] was found to result from a C→G mutation at the second position of codon 95 on an α1-globin gene, and Hb Setif [α94(G1)Asp→Tyr] resulted from a G→T mutation at the first position of codon 94 on an α2-globin gene. Quantification of Hb St. Luke's (11.1 ± 1.12%) and Hb Setif (14.7 ± 2.22%) in peripheral blood hemolysates indicated that, in the absence of either an α- or a β-thalassemia allele, the protein products of the α1- and α2-globin genes were nearly equal in quantity. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/28024 |
Appears in Collections: | Scholarly Works - FacM&SPB |
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Characterization_and_locus_assignment_of_two_α-globin_variants_present_in_the_Maltese_population_1999.pdf Restricted Access | 750 kB | Adobe PDF | View/Open Request a copy |
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