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Title: | pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia |
Authors: | Tucker, Stephen J. Imbrici, Paola Salvatore, Lorena D'Adamo, Maria Cristina Pessia, Mauro |
Keywords: | Potassium channels Monoclonal antibody probes Acidification Immunohistochemistry Kidney tubules |
Issue Date: | 2000 |
Publisher: | The American Society for Biochemistry and Molecular Biology, Inc. |
Citation: | Tucker, S. J., Imbrici, P., Salvatore, L., D'Adamo, M. C., & Pessia, M. (2000). pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia. Journal of Biological Chemistry, 275(22), 16404-16407. |
Abstract: | The physiological role of the inwardly rectifying potassium channel, Kir5.1, is poorly understood, as is the molecular identity of many renal potassium channels. In this study we have used Kir5.1-specific antibodies to reveal abundant expression of Kir5.1 in renal tubular epithelial cells, where Kir4.1 is also expressed. Moreover, we also show that Kir5.1/Kir4.1 heteromeric channel activity is extremely sensitive to inhibition by intracellular acidification and that this novel property is conferred predominantly by the Kir5.1 subunit. These findings suggest that Kir5.1/Kir4.1 heteromeric channels are likely to exist in vivo and implicate an important and novel functional role for the Kir5.1 subunit. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/28262 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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pH_Dependence_of_the_inwardly_rectifying_potassium_channel_2000.pdf | 192.26 kB | Adobe PDF | View/Open |
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