Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/28262
Title: pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia
Authors: Tucker, Stephen J.
Imbrici, Paola
Salvatore, Lorena
D'Adamo, Maria Cristina
Pessia, Mauro
Keywords: Potassium channels
Monoclonal antibody probes
Acidification
Immunohistochemistry
Kidney tubules
Issue Date: 2000
Publisher: The American Society for Biochemistry and Molecular Biology, Inc.
Citation: Tucker, S. J., Imbrici, P., Salvatore, L., D'Adamo, M. C., & Pessia, M. (2000). pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia. Journal of Biological Chemistry, 275(22), 16404-16407.
Abstract: The physiological role of the inwardly rectifying potassium channel, Kir5.1, is poorly understood, as is the molecular identity of many renal potassium channels. In this study we have used Kir5.1-specific antibodies to reveal abundant expression of Kir5.1 in renal tubular epithelial cells, where Kir4.1 is also expressed. Moreover, we also show that Kir5.1/Kir4.1 heteromeric channel activity is extremely sensitive to inhibition by intracellular acidification and that this novel property is conferred predominantly by the Kir5.1 subunit. These findings suggest that Kir5.1/Kir4.1 heteromeric channels are likely to exist in vivo and implicate an important and novel functional role for the Kir5.1 subunit.
URI: https://www.um.edu.mt/library/oar//handle/123456789/28262
Appears in Collections:Scholarly Works - FacM&SPB

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