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Title: ACE gene polymorphism as a prognostic indicator in patients with type 2 diabetes and established renal disease
Authors: Fava, Stephen
Azzopardi, Joseph
Ellard, Sian
Hattersley, Andrew T.
Keywords: Kidneys -- Diseases
Genetic polymorphisms
Diabetes Mellitus, Type 2
Issue Date: 2001
Publisher: BMJ
Citation: Fava, S., Azzopardi, J., Ellard, S., & Hattersley, A. T. (2001). ACE gene polymorphism as a prognostic indicator in patients with type 2 diabetes and established renal disease. Diabetes Care, 24(12), 2115-2120.
Abstract: OBJECTIVE - To investigate whether the DD genotype is a predictor of mortality and of the decline in renal function in patients with type 2 diabetes and established nephropathy. RESEARCH DESIGN AND METHODS - A total of 56 such patients of Maltese Caucasian descent were recruited, and their ACE genotype was determined. Serum creatinine was estimated approximately every 4 months. The glomerular nitration rate (GFR) was calculated according to the Cockroft-Gault formula, and rate of change was determined by regression analysis. RESULTS - The rate of change in calculated GFR was -7.76 ml • min-1• year-1 in those with the DD genotype (n = 31) and -1.17 ml • min-1 • h-1 in those with the ID or II genotype (n = 25) (P < 0.01). The 3-year mortality was 45.2% in the DD group compared with 20.0% in the ID/11 group (P < 0.05). CONCLUSIONS - The DD genotype of the ACE gene polymorphism is associated with a more rapid decline in renal function and higher mortality in type 2 diabetic patients with established nephropathy.
Description: Acknowledgments—This study was partly supported by the Association of Physicians of U.K. and Ireland. We thank Dr. Peter Watkins for his help and support in initiating these studies. We would also like to thank Dr. Alex Aquilina and Janice Barbara Gatt, Department of Pathology, St. Luke’s Hospital, Malta for their technical assistance.
Appears in Collections:Scholarly Works - FacM&SMed

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