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Title: Alternate organization of α G-Philadelphia globin genes among US Black and Italian Caucasian heterozygotes
Authors: Sciarratta, Giuseppina V.
Sansone, Gennaro
Ivaldi, Giovanni L.
Felice, Alex E.
Huisman, Titus Hendrik Jan
Keywords: European Continental Ancestry Group
African Continental Ancestry Group
Hemoglobin polymorphisms
Issue Date: 1984
Publisher: Taylor & Francis
Citation: Sciarratta, G. V., Sansone, G., Ivaldi, G., Felice, A. E., & Huisman, T. H. J. (1984). Alternate organization of α G-Philadelphia globin genes among US Black and Italian Caucasian heterozygotes. Hemoglobin, 8(6), 537-547.
Abstract: Seven Hb G-Philadelphia (Hb G) heterozygotes from three Caucasian families from Northern Italy and Sar-degna were found to have proportions of Hb G averaging 23% This value is considerably lower than the 34% or 48% found in Blacks from the Southeastern U.S.A. in whom the αG gene is in linkage with αthalassernia-2, i.e. the α αG/αalpha; or αd̀αG/αd̀ α genotypes, Gene mapping identified tandem organization of the αGgene in cis with a normal αA gene, i.e. the αalpha;G/αalpha; genotype, among the Hb G heterozygotes from Italy. The data on the Italian heterozygotes are similar to those obtained by Bruzdzinski et al (14) on a Black family. These results indicate alternate organization of the αGgenes probably across racial or ethnic boundaries. Comparison of the mean cellular globin amount of αG/αG gene/cell among Hb Gheterozygotes with 4, 3, 2 or 1 α globin genes (i.e. αA + αG) revealed considerable reactivation of individual α genes in conditions of mild to severe α globin deficiencies.
Description: The authors wish to thank Mrs. M.P. Cleek and Mrs . A.L. Reese for technical assistance. This research was supported in part by USPHS Research Grants HLB-05168 and HLB-15158, by designated research funds of the Veterans Administration, and by grants of the Minister0 della Publica Istruzione, Roma, Italy.
Appears in Collections:Scholarly Works - FacM&SPB

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