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dc.contributor.authorMagri, Caroline Jane-
dc.contributor.authorXuereb, Robert G.-
dc.contributor.authorFava, Stephen-
dc.identifier.citationMagri, C. J., Xuereb, R. G., & Fava, S. (2014). Non-dipping heart rate and microalbuminuria in type 2 diabetes mellitus. Cardiology, 129(1), 28-35.en_GB
dc.descriptionAcknowledgements: The authors would like to like to thank all the staff at Diabetes Centre, Cardiac Laboratory, Biochemistry and Immunology Laboratory, Mater Dei Hospital, for their continuous help and support while carrying out this study.en_GB
dc.description.abstractObjectives: The aim of this study was to identify factors which are independently associated with non-dipping heart rate (HR) in a type 2 diabetic population at high risk of cardiovascular disease. Methods: The study recruited 179 type 2 diabetic subjects with a mean diabetes duration of 18.3 years and with proliferative retinopathy. All underwent 24-hour blood pressure and HR monitoring, and were assessed for markers of inflammation, insulin resistance, albuminuria, presence of peripheral neuropathy and peripheral vascular disease. Subjects whose night-time HR did not decrease by more than 10% as compared to daytime readings were classified as non-dippers. Results: Univariate analysis revealed that non-dippers had significantly higher logarithmic albumin-creatinine ratio (ACR; p = 0.001) and higher platelet count (p = 0.014). Also, non-dippers were more likely to be on β-blockers (p = 0.037). Binary logistic regression analysis showed that logarithmic ACR (p = 0.001) and platelet count (p = 0.026) were independent predictors of non-dipping HR, even when correcting for β-blocker use. Conclusions: In this high-risk type 2 diabetic population, non-dipping HR was independently associated with ACR and platelet count, suggesting that non-dipping HR might give an indication of underlying generalised atherosclerosis in diabetic patients. Also, non-dipping HR may represent a novel mechanism explaining the association of nephropathy with cardiovascular events. This merits further study.en_GB
dc.subjectBlood pressureen_GB
dc.subjectCardiovascular system -- Diseases -- Risk factorsen_GB
dc.subjectDiabetes Mellitus, Type 2en_GB
dc.titleNon-dipping heart rate and microalbuminuria in type 2 diabetes mellitusen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
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