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Title: | Behavioral fragmentation in the D1CT- 7 mouse model of Tourette’s syndrome |
Authors: | Santangelo, Andrea Bortolato, Marco Mosher, Laura J. Crescimanno, Giuseppe Di Giovanni, Giuseppe Cassioli, Emanuele Ricca, Valdo Casarrubea, Maurizio |
Keywords: | Tourette syndrome Tic disorders Nervous system -- Diseases |
Issue Date: | 2018 |
Publisher: | John Wiley & Sons Ltd. |
Citation: | Santangelo, A., Bortolato, M., Mosher, L. J., Crescimanno, G., Di Giovanni, G., Cassioli, E., ... & Casarrubea, M. (2018). Behavioral fragmentation in the D1CT‐7 mouse model of Tourette's syndrome. CNS Neuroscience & Therapeutics. |
Abstract: | AIM: The transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS. METHODS: The behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed. Analyses of transition probabilities among behaviors further provided an overall picture of the behavioral dynamics. RESULTS: T-patterns and transition matrices revealed in D1CT-7 mice a clear-cut hyperactivity compared to controls, with a lower behavioral organization and a marked shift from cautious sniffing toward locomotion. Moreover, the behavioral patterns of the transgenic mice were pervasively disturbed by intrusive tic-like HBT leading to a marked fragmentation of the behavior. Novel exposure to open field provoked a transient inhibitory control over the disrupting phenotype. CONCLUSION: The results of this study show that the D1CT-7 mouse model is subjected to a behavioral fragmentation, with repercussions going beyond the simple tic-like phenomenon. These phenotypes are strikingly akin to behavioral problems observed in patients with TS and further validate the power of this model in summarizing pivotal behavioral aspects of TS. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/29653 |
Appears in Collections: | Scholarly Works - FacM&SPB |
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File | Description | Size | Format | |
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Behavioral_fragmentati_n_in_the_D1CT-7_mouse_model_of_Tourettes_syndrome_2018.pdf Restricted Access | 1.06 MB | Adobe PDF | View/Open Request a copy |
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