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Title: Behavioral fragmentation in the D1CT- 7 mouse model of Tourette’s syndrome
Authors: Santangelo, Andrea
Bortolato, Marco
Mosher, Laura J.
Crescimanno, Giuseppe
Di Giovanni, Giuseppe
Cassioli, Emanuele
Ricca, Valdo
Casarrubea, Maurizio
Keywords: Tourette syndrome
Tic disorders
Nervous system -- Diseases
Issue Date: 2018
Publisher: John Wiley & Sons Ltd.
Citation: Santangelo, A., Bortolato, M., Mosher, L. J., Crescimanno, G., Di Giovanni, G., Cassioli, E., ... & Casarrubea, M. (2018). Behavioral fragmentation in the D1CT‐7 mouse model of Tourette's syndrome. CNS Neuroscience & Therapeutics.
Abstract: AIM: The transgenic D1CT-7 mouse is one of the best-characterized animal models of Tourette's syndrome (TS), exhibiting spontaneous tic-like Head-Body Twitches (HBT) and deficits in sensorimotor gating. This study is aimed at evaluating the behavioral dynamics of these mutants and their potential relevance to TS. METHODS: The behavior of D1CT-7 and Wild Type littermates was firstly assessed by considering frequencies and durations. To detect recurrent real-time behavioral sequences, the multivariate T-pattern analysis was employed. Analyses of transition probabilities among behaviors further provided an overall picture of the behavioral dynamics. RESULTS: T-patterns and transition matrices revealed in D1CT-7 mice a clear-cut hyperactivity compared to controls, with a lower behavioral organization and a marked shift from cautious sniffing toward locomotion. Moreover, the behavioral patterns of the transgenic mice were pervasively disturbed by intrusive tic-like HBT leading to a marked fragmentation of the behavior. Novel exposure to open field provoked a transient inhibitory control over the disrupting phenotype. CONCLUSION: The results of this study show that the D1CT-7 mouse model is subjected to a behavioral fragmentation, with repercussions going beyond the simple tic-like phenomenon. These phenotypes are strikingly akin to behavioral problems observed in patients with TS and further validate the power of this model in summarizing pivotal behavioral aspects of TS.
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