A review of studies investigating the dielectric properties of biological tissues for application in hyperthermia and microwave thermal ablation

Abstract

Heating of biological tissues beyond 40 C has become an established method of treating a number of diseases, most notably tumours, where hyperthermia and thermal ablation are important modalities. In some interventions, tissue temperatures reached can even go beyond 100 C, and demand precise knowledge of tissue dielectric properties and how these vary with frequency and temperature in order to facilitate accurate computational simulations for preclinical planning. This paper reviews the available literature concerning dielectric properties of biological tissues and their temperature dependence, focusing on the frequencies of 915 MHz and 2.45 GHz, at which most of the studies reviewed investigate predominantly liver tissue. In this review a comparative analysis of the results obtained by different research groups are presented in the different studies is also made, indicating possible limiting factors in the different studies. These studies propose a number of different models which could be used to describe temperature dependence. Due to the prevalence of liver investigations, it would be ideal to conduct further studies on different biological tissues.