Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/48702
Title: Cost effectiveness of TNF-๐›ผ inhibitors in rheumatoid arthritis
Authors: Said, Cynthia
Coleiro, Bernard
Zarb Adami, Maurice
Azzopardi, Lilian M.
Serracino-Inglott, Anthony
Keywords: Tumor necrosis factor -- Receptors
Rheumatoid arthritis -- Case studies
Patients -- Care
Issue Date: 2013
Publisher: Hindawi
Citation: Said, C., Coleiro, B., Zarb Adami, M., Azzopardi, L. M., & Serracino Inglott, A. (2013). Cost effectiveness of TNF-๐›ผ inhibitors in rheumatoid arthritis. International journal of inflammation, 2013, 1-9.
Abstract: Background. TNF-๐›ผ inhibitors have shown to be effective in reducing disease activity and improving the quality of life. Due to the high costs associated with acquisition of this treatment, this study was undertaken to evaluate the ICER of TNF-๐›ผ antagonists (etanercept, adalimumab, and infliximab) in improving the quality of life. Methods.The HAQ and SF-36 were administered at phases 1, 2, and 3, in order to assess the improvement in the QOL. Suppression of disease activity was assessed through the DAS-28. Results. Statistically significant improvements (๐‘ƒ < 0.05) were noted for the SF-36 and HAQ after 3 months and for the DAS-28 after 6 months of TNF-๐›ผ inhibitor therapy.The mean ICER per 10% improvement in the HAQ, DAS-28, and SF-6D were C1976.5, C2086.5, and C2316.4, respectively, following 6 months of TNF-๐›ผ intervention. Most favorable ICERs were reported from a patient who had to undergo surgical intervention whilst on DMARD therapy. Conclusion. Significant improvement was observed in patientsโ€™ quality of life, after a short timeframe of 6 months. Such data is useful information in the light of convincing policy makers, in terms of providing access to the medications to individual patients on national health service schemes.
URI: https://www.um.edu.mt/library/oar/handle/123456789/48702
Appears in Collections:Scholarly Works - FacM&SPha

Files in This Item:
File Description SizeFormat 
Cost_effectiveness_of_TNF_๐›ผ_inhibitors_in_rheumatoid_arthritis.pdf1.35 MBAdobe PDFView/Open


Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.