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https://www.um.edu.mt/library/oar/handle/123456789/48811| Title: | Improving the yield in orthoesterification of steroids |
| Authors: | Sammut Bartolo, Nicolette Mallia, Christopher D. Vella, Janis Serracino-Inglott, Anthony Ferrito, Victor |
| Keywords: | Steroids Steroids -- Analysis Tetrahydrofuran Pyridinium compounds Catalysis |
| Issue Date: | 2015-09 |
| Publisher: | University of Malta. Department of Pharmacy |
| Citation: | Sammut Bartolo, N., Mallia, C. D., Vella, J., Serracino Inglott, A., & Ferrito, V. (2015, September). Improving the yield in orthoesterification of steroids. Poster session presented at the FIP 75th World Congress of Pharmacy and Pharmaceutical Sciences, Düsseldorf, Germany. |
| Abstract: | A poster presentation about improving the yield in orthoesterification of steroids. Introduction: Steroids are used to treat various conditions from asthma to skin inflammation. Orthoesterification of steroids at C17 and C21 leads to the formation of compounds which are more potent than their parent steroids. Steroid orthoesters are synthesized by reacting a selected steroid with the respective orthoester. The parent steroid should have two hydroxyl groups situated in close proximity to react with the orthoester, for example at C17 and C21. An acid is used to catalyse the reaction. Aims: To synthesise and improve the yield of the orthoesterification of a steroidal compound. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/48811 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Improving_the_yield_in_orthoesterification_of_steroids_2015.pdf | 602.38 kB | Adobe PDF | View/Open |
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