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https://www.um.edu.mt/library/oar/handle/123456789/49071| Title: | Association of the CYP2C19 *2 allele on the occurrence of in-stent restenosis in patients undergoing coronary stenting |
| Authors: | Wirth, Francesca Zahra, Graziella Xuereb, Robert G. Barbara, Christopher Fenech, Albert Azzopardi, Lilian M. |
| Keywords: | Clopidogrel Coronary arteries -- Stenosis -- Malta Coronary heart disease -- Chemotherapy Stents (Surgery) |
| Issue Date: | 2015-06 |
| Publisher: | Springer Dordrecht |
| Citation: | Wirth, F., Zahra, G., Xuereb, R. G., Barbara, C., Fenech, A., & Azzopardi, L. M. (2015, June). Association of the CYP2C19 *2 allele on the occurrence of in-stent restenosis in patients undergoing coronary stenting. Nordic Social Pharmacy and Health Services Research Conference & The Nordic Networking Group for Clinical Pharmacy, Tartu, Estonia. 32. |
| Abstract: | Background and objectives: Appropriate function of CYP2C19 is required to convert clopidogrel to its active metabolite to exert its antiplatelet effect. Presence of CYP2C19 loss-of-function *2 allele is associated with a decreased response to clopidogrel which may lead to adverse cardiac events. The objective was to determine whether an association exists between presence of CYP2C19*2 allele and occurrence of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/49071 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
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