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https://www.um.edu.mt/library/oar/handle/123456789/49496| Title: | Drug design of molecules binding to the 5-HT receptor using a bioisosteric approach |
| Authors: | Schembri, Maria Shoemake, Claire Azzopardi, Lilian M. |
| Keywords: | Lead compounds Ligand binding (Biochemistry) Antidepressants -- Structure Molecular structure Drugs -- Design |
| Issue Date: | 2013-08 |
| Publisher: | University of Malta. Department of Pharmacy |
| Citation: | Schembri, M., Shoemake, C., & Azzopardi, L. M. (2013, August). Drug design of molecules binding to the 5-HT receptor using a bioisosteric approach. Poster session presented at the International Pharmaceutical Federation (FIP) World Congress, Dublin, Ireland. |
| Abstract: | A poster presentation regarding the drug design of molecules binding to the 5-HT receptor using a bioisosteric approach. Introduction: A strategy used to improve a lead compound is based on the concept of bioisosterism. In bioisosterism, the properties of a compound are fine-tuned by the replacement of some groups or fragments in a molecule, without affecting its overall biological activity. Aims: - To design molecules binding to the 5-HT receptor using a bioisosteric approach. - To compare the affinity of the generated bioisosteres to the affinity of the endogenous ligands. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/49496 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Drug_design_of_molecules_binding_to_the_5_HT_receptor_using_a_bioisosteric_approach_2013.pdf | 917.66 kB | Adobe PDF | View/Open |
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