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https://www.um.edu.mt/library/oar/handle/123456789/49708| Title: | Pharmacogenetic testing for personalisation of statin therapy |
| Authors: | Cerdá Iñesta, Judith Wirth, Francesca Mifsud Buhagiar, Luana Zahra, Graziella Xuereb, Robert G. Barbara, Christopher Serracino-Inglott, Anthony |
| Keywords: | Statins (Cardiovascular agents) -- Research -- Malta Statins (Cardiovascular agents) -- Side effects Pharmacogenetics Personalized medicine Muscles -- Diseases Hospital pharmacies |
| Issue Date: | 2019-03 |
| Publisher: | University of Malta. Department of Pharmacy |
| Citation: | Cerda Inesta, J., Wirth, F., Mifsud Buhagiar, L., Zahra, G., Xuereb, R. G., Barbara, C., & Serracino-Inglott, A. (2019, March). Pharmacogenetic testing for personalisation of statin therapy. Poster session presented at the 24th Congress of the European Association of Hospital Pharmacists (EAHP), Barcelona, Spain. Cerdá Iñesta J., Wirth F., Zahra G., et al (2019). 5PSQ-021 Pharmacogenetic testing for personalisation of statin therapy. European Journal of Hospital Pharmacy 2019, 26, A211. |
| Abstract: | A poster presentation regarding pharmacogenetic testing for personalisation of statin therapy. Introduction: The SLCO1B1 protein facilitates the hepatic uptake of simvastatin. The SLCO1B1 c.521T>C genetic polymorphism (rs4149056) decreases the function of SLCO1B1 and is a predictor of simvastatin-induced myopathy. SLCO1B1 pharmacogenetic testing and pharmacist interpretation of test results are a step forward to personalise statin therapy. Aims: • To classify a cohort of cardiac patients on simvastatin according to SLCO1B1 c.521T>C genotype and function • To investigate the correlation of SLCO1B1 genotype and function to myopathy risk. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/49708 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Pharmacogenetic_testing_for_personalisation_of_statin_therapy_2019.pdf | 995.51 kB | Adobe PDF | View/Open | |
| Pharmacogenetic_testing_for_personalization_of_statin_therapy(2019).pdf | 77.54 kB | Adobe PDF | View/Open |
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