Chronopharmacology in type I diabetes

Abstract

A poster presentation regarding chronopharmacology in type I diabetes. Introduction: ‘Chronopharmacology is the investigative science that elucidates the biological rhythm dependencies of medication’. This signifies the investigation of the effects of drugs on biological timing and the effect of circadian rhythm on the pharmacokinetics of the drug. In this study Insulin was the drug under investigation. Aims: 1. The possibility of a relation between timely administration of short acting exogenous Insulin 20-30 minutes before meals, and effective glycaemic control. 2. The possibility of a relation between the timely administration of intermediate or long acting exogenous insulin and effective glycaemic control. 3. Presence of Dawn and Somogyi phenomena and its correlation with glycaemic control. 4. The possibility of improvement in the glycaemic profile of Group 2 patients after counselling on regular timed insulin administration and/or the possibility of changing the insulin type/insulin regime appropriately.