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https://www.um.edu.mt/library/oar/handle/123456789/50506| Title: | Comparison between a point-of-care and a laboratory-based CYP2C19*2 genotyping assay for pharmacist-led personalisation of antiplatelet therapy |
| Authors: | Wirth, Francesca Zahra, Graziella Xuereb, Robert G. Barbara, Christopher Fenech, Albert Azzopardi, Lilian M. |
| Keywords: | Blood platelet disorders Blood platelets -- Aggregation Clopidogrel Coronary arteries -- Stenosis Point-of-care testing Cytochrome P-450 CYP2C19 Pharmacists -- Practice |
| Issue Date: | 2015-10 |
| Publisher: | University of Malta. Department of Pharmacy |
| Citation: | Wirth, F., Zahra, G., Xuereb, R. G., Barbara, C., Fenech, A., & Azzopardi, L. M. (2015, October). Comparison between a point-of-care and a laboratory-based CYP2C19*2 genotyping assay for pharmacist-led personalisation of antiplatelet therapy. Poster session presented at the ACCP Global Conference on Clinical Pharmacy, San Francisco, USA. |
| Abstract: | A poster presentation regarding a comparison between a point-of-care and a laboratory-based CYP2C19*2 genotyping assay for pharmacist-led personalisation of antiplatelet therapy. Introduction: The novel point-of-care (POC) Spartan™ RX CYP2C19 genotyping assay rapidly identifies presence of the CYP2C19 loss-offunction ‘*2’ variant allele and can be applied to personalise antiplatelet therapy at the start of treatment. This POC assay has not been previously compared to laboratory-based CYP2C19*2 genotyping using reverse dot-blot (RDB) hybridisation. Aims: To apply the Spartan™ RX assay for pharmacist-led CYP2C19*2 genotyping to personalise antiplatelet therapy in patients undergoing percutaneous coronary intervention (PCI) and compare it to a laboratory-based CYP2C19*2 genotyping assay which uses a robust and accurate RDB hybridisation technique. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/50506 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Comparison_between_a_point_of_care_and_a_laboratory_based_CYP2C19_2_genotyping_assay_2015.pdf | 549.98 kB | Adobe PDF | View/Open |
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