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https://www.um.edu.mt/library/oar/handle/123456789/54126| Title: | The role of pharmacogenetics in rediscovering old drugs : spotlight on amitriptyline |
| Authors: | Mifsud Buhagiar, Luana Grech, Anton Casha, Marilyn Serracino-Inglott, Anthony LaFerla, Godfrey |
| Keywords: | Pharmacogenetics -- Research Drugs -- Prescribing Pharmacogenetics -- Testing Personalized medicine Antidepressants |
| Issue Date: | 2017 |
| Publisher: | University of Malta. Department of Pharmacy |
| Citation: | Mifsud Buhagiar, L., Grech, A., Casha, M., Serracino-Inglott, A., & LaFerla, G. (2017). The role of pharmacogenetics in rediscovering old drugs : spotlight on amitriptyline. Poster session presented at the ESPT Fourth Conference. Catania, Italy. |
| Abstract: | A poster presentation regarding the role of pharmacogenetics in rediscovering old drugs with a special spotlight on amitriptyline. Introduction: Tricyclic antidepressants (TCAs) are often overlooked in clinical practice on claims of poor tolerability, notwithstanding their potential advantages in efficacy and pharmacoeconomics. Most data available on TCAs derives from an era when genotyping studies were not available. While still being used in psychiatry, prescribing trends of amitriptyline are increasing in the context of pain management. The effect of CYP2D6 and CYP2C19 polymorphisms on individual amitriptyline and metabolites exposure may predispose to adverse events or treatment failure. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/54126 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ESPT Poster.pdf | 859.15 kB | Adobe PDF | View/Open |
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