Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/77240
Title: Studies on the N-oxidation of heterocycles of pharmacological importance : the N-oxidation of indoles
Authors: Felice, Maryanne (1977)
Keywords: Heterocyclic compounds
Indole
Pharmacology
Issue Date: 1977
Citation: Felice, M. (1977). Studies on the N-oxidation of heterocycles of pharmacological importance : the N-oxidation of indoles (Master’s dissertation).
Abstract: Hepatic microsomal oxidation on the nitrogen on the indole ring has been investigated with 2-phenylindole as substrate. N-hydroxy-2-phenylindole has been isolated following incubation of different concentrations of substrate and co-enzymes with whole liver homogenates and microsomal preparations from rabbit and guinea-pig, with and without inducer pretreatment. The hydroxy metabolite has been shown to be identical with N-hydroxy-2-phenylindole, obtained by chemical synthesis, through its TLC and GC behaviour and its IR and NMR spectral characteristics
Description: M.PHIL.
URI: https://www.um.edu.mt/library/oar/handle/123456789/77240
Appears in Collections:Dissertations - FacM&S - 1975-1977
Dissertations - FacM&SPha - 1977-1995

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