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Title: Pathogenesis of endocrine thyroid cancer
Authors: Mallia, Nicola
Vassallo, Josanne
Keywords: Thyroid gland -- Cancer
Endocrine gland neoplasms
Thyroid neoplasms
Issue Date: 2015
Publisher: Malta Medical Journal
Citation: Malta Medical Journal. 2015, Vol. 27(4), p. 28-33
Abstract: This review aims to discuss the different genetic alterations that may come about and thus give rise to thyroid cancer. The importance of understanding the pathogenesis of this disease is in the use of these genetic alterations as prognostic markers and as targets in treatment. Principal alterations to these central pathways, namely the MAPK pathway and PI3K/AKT pathway, are mutations, increase in gene number, methylations and translocations. The effects of the environment on the progression of thyroid cancer, such as the effects of the microenvironment and exposure to endocrine disruptors, will also be discussed.
Appears in Collections:MMJ, Volume 27, Issue 4
MMJ, Volume 27, Issue 4
Scholarly Works - FacM&SMed

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