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Title: | Phenobarbital and other barbiturates |
Other Titles: | Atlas of epilepsies |
Authors: | Mifsud, Janet |
Keywords: | Phenobarbital Barbiturates -- Physiological effect Barbiturates -- Analysis Barbiturates -- Toxicology Barbiturates -- Pharmacokinetics |
Issue Date: | 2010 |
Publisher: | Springer |
Citation: | Mifsud, J. (2010). Phenobarbital and other barbiturates. In: C. P. Panayiotopoulos (ed.), Atlas of epilepsies (pp. 1807-1812). Cham: Springer. |
Abstract: | Barbituric acid was first synthesized in 1864 (Fig. 276-1), but it was only in 1912 that Bayer marketed a barbituric acid derivative, phenobarbital, under the trade name Luminal®, as a sedative-hypnotic (Fig. 276-3). Pentobarbital (Nembutal®), a short-acting barbiturate, was discovered in 1930 (Sneader 2005). Chemists have now derived over 2,500 compounds from barbituric acid. In the 1970s, several barbiturates were designated in the United States as controlled substances under the American Controlled Substances Act of 1970, and in 1971 the Convention on psychotropic substances signed in Vienna scheduled several barbiturates. Yet phenobarbital (or phenobarbitone as it is formally known) is still the most widely used anticonvulsant worldwide, especially in developing countries (Kwan and Brodie 2004). [excerpt] |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/87764 |
Appears in Collections: | Scholarly Works - FacM&SCPT |
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File | Description | Size | Format | |
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atlas-of-epilepsies-Phenobarbital and Other Barbiturates.pdf Restricted Access | 219.77 kB | Adobe PDF | View/Open Request a copy |
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