Please use this identifier to cite or link to this item:
Title: Phenobarbital and other barbiturates
Other Titles: Atlas of epilepsies
Authors: Mifsud, Janet
Keywords: Phenobarbital
Barbiturates -- Physiological effect
Barbiturates -- Analysis
Barbiturates -- Toxicology
Barbiturates -- Pharmacokinetics
Issue Date: 2010
Publisher: Springer
Citation: Mifsud, J. (2010). Phenobarbital and other barbiturates. In: C. P. Panayiotopoulos (ed.), Atlas of epilepsies (pp. 1807-1812). Cham: Springer.
Abstract: Barbituric acid was first synthesized in 1864 (Fig. 276-1), but it was only in 1912 that Bayer marketed a barbituric acid derivative, phenobarbital, under the trade name Luminal®, as a sedative-hypnotic (Fig. 276-3). Pentobarbital (Nembutal®), a short-acting barbiturate, was discovered in 1930 (Sneader 2005). Chemists have now derived over 2,500 compounds from barbituric acid. In the 1970s, several barbiturates were designated in the United States as controlled substances under the American Controlled Substances Act of 1970, and in 1971 the Convention on psychotropic substances signed in Vienna scheduled several barbiturates. Yet phenobarbital (or phenobarbitone as it is formally known) is still the most widely used anticonvulsant worldwide, especially in developing countries (Kwan and Brodie 2004). [excerpt]
Appears in Collections:Scholarly Works - FacM&SCPT

Files in This Item:
File Description SizeFormat 
atlas-of-epilepsies-Phenobarbital and Other Barbiturates.pdf
  Restricted Access
219.77 kBAdobe PDFView/Open Request a copy

Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.