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https://www.um.edu.mt/library/oar/handle/123456789/134055| Title: | Towards understanding P-gp resistance : a case study of the antitumour drug cabazitaxel |
| Authors: | Baisch, Ulrich Vella-Zarb, Liana |
| Keywords: | Antineoplastic agents Glycoproteins Drug resistance in cancer cells X-ray crystallography Molecular structure Structure-activity relationships (Biochemistry) Pharmaceutical chemistry |
| Issue Date: | 2014 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Baisch, U., & Vella-Zarb, L. (2014). Towards understanding P-gp resistance: A case study of the antitumour drug cabazitaxel. CrystEngComm, 16(44), 10161-10164. |
| Abstract: | A detailed structural study and Hirshfeld surface analysis of cabazitaxel in its anhydrous, hydrated and solvated forms have revealed that the three-dimensional architecture of the drug molecule is retained regardless of the crystalline environment. This prompted comparison with its taxane predecessors, suggesting key factors contributing to cabazitaxel's poor affinity to P-gp. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/134055 |
| Appears in Collections: | Scholarly Works - FacSciChe |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Towards_understanding_P-gp_resistance_A_case_study_of_the_antitumour_drug_cabazitaxel(2014).pdf Restricted Access | 2.41 MB | Adobe PDF | View/Open Request a copy |
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