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dc.contributor.authorHoogendijk, Arie J.-
dc.contributor.authorVught, Lonneke A. van-
dc.contributor.authorWiewel, Maryse A.-
dc.contributor.authorFuhler, Gwenny M.-
dc.contributor.authorBelkasim-Bohoudi, Hakima-
dc.contributor.authorHorn, Janneke-
dc.contributor.authorSchultz, Marcus J.-
dc.contributor.authorScicluna, Brendon P.-
dc.contributor.authorPeppelenbosch, Maikel P.-
dc.contributor.authorVeer, Cornelis Van't-
dc.contributor.authorVos, Alex F. de-
dc.contributor.authorPoll, Tom van der-
dc.identifier.citationHoogendijk, A. J., van Vught, L. A., Wiewel, M. A., Fuhler, G. M., Belkasim-Bohoudi, H., Horn, J., ... & van der Poll, T. (2019). Kinase activity is impaired in neutrophils of sepsis patients. Haematologica, 104(6), e233.en_GB
dc.description.abstractSepsis is a complex clinical condition that arises from multiple interacting tissues and unbalanced cell-specific host response mechanisms. Neutrophils are the most abundant circulating leukocytes and form the primary line of defense against pathogens. Upon activation and subsequent extravasation, neutrophils can engage pathogens by a broad set of actions, including phagocytosis, production of reactive oxygen species, release of antimicrobial peptides and by undergoing NETosis. Kinases play an integral role in regulating and enabling intracellular signaling cascades that control these, for neutrophil function, essential processes: for example, NADPH oxygenase assembly is regulated via Raf (RAF proto-oncogene serine/threonine-protein kinase), ERK (MAPK1/3) and MEK kinases3 and the balance of P38 MAPK and ERK upstream of GRK2 (G protein-coupled receptor kinase 2) as well as PAK and PI3K/AKT activity controls neutrophil migration. However, knowledge on kinome-wide regulation of kinases in primary neutrophils during sepsis and critical illness is limited. Using a kinome profiling approach we here uncover that, relative to patients with non-infectious critical illness, sepsis patients present a suppressed neutrophil kinase activity profile.en_GB
dc.publisherFerrata-Storti Foundationen_GB
dc.subjectEnzyme activationen_GB
dc.subjectNeutrophils -- Immunologyen_GB
dc.subjectSepticemia -- Diagnosisen_GB
dc.titleKinase activity is impaired in neutrophils of sepsis patientsen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
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