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DC Field | Value | Language |
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dc.contributor.author | Wiewel, Maryse A. | - |
dc.contributor.author | Vught, Lonneke A. van | - |
dc.contributor.author | Scicluna, Brendon P. | - |
dc.contributor.author | Hoogendijk, Arie J. | - |
dc.contributor.author | Frencken, Jos F. | - |
dc.contributor.author | Zwinderman, Aeilko H. | - |
dc.contributor.author | Horn, Janneke | - |
dc.contributor.author | Cremer, Olaf L. | - |
dc.contributor.author | Bonten, Marc M.J. | - |
dc.contributor.author | Schultz, Marcus J. | - |
dc.contributor.author | Poll, Tom van der | - |
dc.date.accessioned | 2022-07-01T09:30:06Z | - |
dc.date.available | 2022-07-01T09:30:06Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Wiewel, M. A., Van Vught, L. A., Scicluna, B. P., Hoogendijk, A. J., Frencken, J. F., Zwinderman, A. H., ... & Van Der Poll, T. (2017). Prior use of calcium channel blockers is associated with decreased mortality in critically ill patients with sepsis: a prospective observational study. Critical Care Medicine, 45(3), 454-463. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/98683 | - |
dc.description.abstract | Objectives: Experimental studies suggest that calcium channel blockers can improve sepsis outcome. The aim of this study was to determine the association between prior use of calcium channel blockers and the outcome of patients admitted to the ICU with sepsis. | en_GB |
dc.description.abstract | Design: A prospective observational study. | en_GB |
dc.description.abstract | Setting: The ICUs of two tertiary care hospitals in the Netherlands. | en_GB |
dc.description.abstract | Patients: In total, 1,060 consecutive patients admitted with sepsis were analyzed, 18.6% of whom used calcium channel blockers. | en_GB |
dc.description.abstract | Interventions: None. | en_GB |
dc.description.abstract | Measurements and main results: Considering large baseline differences between calcium channel blocker users and nonusers, a propensity score matched cohort was constructed to account for differential likelihoods of receiving calcium channel blockers. Fifteen plasma biomarkers providing insight in key host responses implicated in sepsis pathogenesis were measured during the first 4 days after admission. Severity of illness over the first 24 hours, sites of infection and causative pathogens were similar in both groups. Prior use of calcium channel blockers was associated with improved 30-day survival in the propensity-matched cohort (20.2% vs 32.9% in non-calcium channel blockers users; p = 0.009) and in multivariate analysis (odds ratio, 0.48; 95% CI, 0.31-0.74; p = 0.0007). Prior calcium channel blocker use was not associated with changes in the plasma levels of host biomarkers indicative of activation of the cytokine network, the vascular endothelium and the coagulation system, with the exception of antithrombin levels, which were less decreased in calcium channel blocker users. | en_GB |
dc.description.abstract | Conclusions: Prior calcium channel blocker use is associated with reduced mortality in patients following ICU admission with sepsis. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Society of Critical Care Medicine and Wolters Kluwer Health, Inc. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Antithrombins | en_GB |
dc.subject | Biochemical markers -- Diagnostic use | en_GB |
dc.subject | Calcium -- Antagonists | en_GB |
dc.subject | Catastrophic illness | en_GB |
dc.subject | Intensive care units | en_GB |
dc.subject | Interleukin-6 | en_GB |
dc.subject | Interleukin-8 | en_GB |
dc.subject | Septicemia -- Diagnosis | en_GB |
dc.title | Prior use of calcium channel blockers is associated with decreased mortality in critically ill patients with sepsis : a prospective observational study | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.contributor.corpauthor | Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1097/CCM.0000000000002236 | - |
dc.publication.title | Critical Care Medicine | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
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