Dr Jean-Paul Ebejer, a lecturer at the Centre for Molecular Medicine and Biobanking at the University of Malta, and collaborators at InhibOx limited, a spin-off company from Oxford University, have recently published a computational study on the physicochemical properties of antibacterial compounds in the peer-reviewed Journal of Cheminformatics.
The continued development of antibiotic resistance in bacteria responsible for common infections is of growing worldwide concern. Many promising antibacterial drug discovery projects fail because the compounds cannot penetrate the bacterial cell wall. As part of ongoing antibacterial drug discovery activities, the researchers have investigated the role of drug physical properties on bacterial cells penetration.
The study, titled 'Are the physicochemical properties of antibacterial compounds really different from other drugs?', challenges the perceived wisdom that antibacterial drugs are 'special' in their property profiles. The results of this data science project have important implications for antibacterial drug discovery.
The study, titled 'Are the physicochemical properties of antibacterial compounds really different from other drugs?', challenges the perceived wisdom that antibacterial drugs are 'special' in their property profiles. The results of this data science project have important implications for antibacterial drug discovery.
The paper is available as open access.
For more information about this research contact Dr Jean-Paul Ebejer.
For more information about this research contact Dr Jean-Paul Ebejer.