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Title: | Nitric oxide-induced inhibition on striatal cells and excitation on globus pallidus neurons : a microiontophoretic study in the rat |
Authors: | Sardo, Pierangelo Ferraro, Giuseppe Di Giovanni, Giuseppe Grutta, Vittorio La |
Keywords: | Basal ganglia Nitric oxide Globus pallidus |
Issue Date: | 2003 |
Publisher: | Elsevier Ireland Ltd. |
Citation: | Sardo, P., Ferraro, G., Di Giovanni, G., & La Grutta, V. (2003). Nitric oxide-induced inhibition on striatal cells and excitation on globus pallidus neurons: a microiontophoretic study in the rat. Neuroscience Letters, 343(2), 101-104. |
Abstract: | Single units were recorded in the striatum and in the globus pallidus (GP) of urethane-anesthetized rats under microiontophoretic administration of either Nω-nitro-l-arginine methyl ester (l-NAME, inhibitor of nitric oxide synthase), or 3-morpholino-sydnonimin-hydrocloride (SIN-1, nitric oxide, NO donor). A steady baseline firing of sporadically discharging striatal neurons (basal firing rate <0.1 spikes/s) was evoked by a pulsed microiontophoretic ejection of glutamate. On striatal neurons, microiontophoretic application of SIN-1 induced a current-dependent inhibition (11/13), whereas l-NAME administration produced a clear excitation (9/9). On GP cells, the administration of SIN-1 had excitatory effects (10/15), whereas the administration of l-NAME reduced the neuronal activity (6/6). We hypothesize that NO could exert an intrinsic regulatory action on the activity of both striatal and GP cells. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/22761 |
Appears in Collections: | Scholarly Works - FacM&SPB |
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