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https://www.um.edu.mt/library/oar/handle/123456789/100079| Title: | Aspirin impairs the carnitine shuttle pathway in redox-compromised yeast cells : implications for cancer chemoprevention and Reye’s syndrome |
| Authors: | Farrugia, Gianluca Saliba, Christian Pistolic, Jelena Benes, Vladimir Vassallo, Neville Grech, Godfrey Borg, Joseph J. Bannister, William H. Balzan, Rena |
| Keywords: | Isopentenoids -- Synthesis Yeast Medicine, Popular Cancer -- Prevention Anti-inflammatory agents Aspirin -- Therapeutic use |
| Issue Date: | 2015 |
| Publisher: | University of Malta. Faculty of Medicine and Surgery |
| Citation: | Farrugia, G., Saliba, C., Pistolic, J., Benes, V., Vassallo, N., Grech G…. Balzan, R. (2015). Aspirin impairs the carnitine shuttle pathway in redox-compromised yeast cells: implications for cancer chemoprevention and Reye’s syndrome. Malta Medical Journal, 27(Supplement), 46. |
| Abstract: | Acetylcoenzyme A (acetyl-CoA) plays an important role in cellular metabolism. It is an essential substrate for energy production in the tricarboxylic acid (TCA) cycle. In yeast cells grown on ethanol as the carbon source, acetyl-CoA is generated in the peroxisomes and cytosol, and then transpOlted into mitochondria by the carnitine shuttle pathway. We use yeast as a eukaryotic model since it offers large experimental advantages in conditions controlled by multiple genes. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/100079 |
| ISSN: | 18133339 |
| Appears in Collections: | Scholarly Works - FacHScABS |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Aspirin_impairs_the_carnitine_shuttle_pathway_in_redox_compromised_yeast_cells.pdf | 108.8 kB | Adobe PDF | View/Open |
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