Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/103734
Title: Anti-endomysial antibody may predict a second endoscopy in coeliac-suspected patients with false negative index duodenal biopsies
Authors: Gerada, Jurgen
Gerada, Eleanor
Grech, Gabriella
Ellul, Pierre
Keywords: Celiac disease -- Diagnosis
Celiac disease -- Patients -- Malta -- Case studies
Intestine, Small -- Biopsy
Issue Date: 2015
Publisher: Austin Publishing Group
Citation: Gerada, J., Gerada, E., Abdilla, S., Grech, G., & Ellul, P. (2015). Anti-Endomysial Antibody May Predict a Second Endoscopy in Coeliac-Suspected Patients with False Negative Index Duodenal Biopsies. Austin Journal of Gastroenterology, 2(1), 1029.
Abstract: Background/aims: A subset of coeliac-suspected patients requires 2 Oesophagogastroduodenoscopies (OGDs) to achieve histological confirmation. Their index OGD would fail to reach diagnosis despite 4 duodenal biopsies suggested by guidelines. We compared this subgroup of patients with other coeliac patients requiring 1 endoscopy and recognize any predictors to identify the former group.
Methods: Coeliac-suspected patients at our department underwent an OGD. Clinical, serological and histological data were retrieved from medical notes. Group 1 comprised patients who achieved diagnosis with 1 OGD. Group 2 required 2 OGDs.
Results: 178 patients underwent an OGD (mean age 47 years; 73.6% females). 12 patients (6.7%) required 2 OGDs. Both groups had the same mean number of duodenal biopsies at their index endoscopy (4.6 vs 4.5, P=0.76). In Group 2, the number of biopsies was higher at the second endoscopy (6.4 vs 4.5, P=0.028). Group 2 showed a negative or lower positivity for anti-EMA (P=0.039) and a lower anti-tTG IgA level (P=0.06) than Group 1.
Conclusion: Anti-EMA seronegativity or low positivity in coeliac-suspected patients indicates the need for more duodenal biopsies to achieve diagnosis and avoiding subsequent OGDs. This finding makes anti-EMA testing crucial in coeliac diagnostics.
URI: https://www.um.edu.mt/library/oar/handle/123456789/103734
ISSN: 23819219
Appears in Collections:Scholarly Works - FacM&SMed



Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.