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Title: Lateral Habenula contribution in Nicotine addiction : focus on Dopamine, GABA and Serotonin Interactions
Authors: Pierucci, Massimo
Pitruzzella, Alessandro
Valentino, Mario
Zammit, Christian
Muscat, Richard
Benigno, Arcangelo
Di Giovanni, Giuseppe
Keywords: Nicotine -- Physiological effect
Drug addiction -- Dopamine
GABA -- Receptors
Brain -- Drug effects
Issue Date: 2011
Publisher: Malta Medical Journal
Citation: Malta Medical Journal. 2011, Vol.23(3), p. 32-37
Abstract: Compelling evidence has shown a pivotal role of dopaminergic function in drug addiction. Recently, the Habenula (Hb) has attracted a great deal of attention as another target for nicotine in the brain because of its role in regulating dopamine (DA), gamma-aminobutyric acid (GABA) and serotonin (5-HT) systems. Nicotine acts binding to acetylcholine receptors that are widely distributed in the brain. Interestingly, the receptor subtypes that mediate nicotine withdrawal responses are highly expressed in the Hb. Moreover, the block of habenular nicotinic receptors in animals chronically treated with nicotine enhances withdrawal responses once nicotine is discontinued. Furthermore, it has been shown how a high dose of nicotine can cause massive degeneration almost exclusively in the medial habenula (MHb) and its output tract, the fasciculus retroflexus. Thus, symptoms associated with nicotine withdrawal may be caused by dysfunctions of the Hb output. Therefore, Hb might be of fundamental importance in the expression of nicotine reinforcing properties and withdrawal. Here, we will focus on the role of the lateral habenula (LHb) on nicotine modulation of DA function and we will evaluate LHb interaction with the rostromedial tegmental nucleus (RMTg), a GABAergic area, and the serotonergic raphé nuclei. Furthermore, as LHb has high density expression of 5-HT2C receptors, these subtypes might be important in the control of its neuronal activity and output to the midbrain monoaminergic and GABAergic systems.
Appears in Collections:MMJ, Volume 23, Issue 3
MMJ, Volume 23, Issue 3
Scholarly Works - FacM&SAna
Scholarly Works - FacM&SPB

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