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https://www.um.edu.mt/library/oar/handle/123456789/129784| Title: | DABCO/Amberlyst® 15-cocatalysed one-pot three-component aza-Morita–Baylis–Hillman reaction under green conditions |
| Authors: | Bosica, Giovanna De Nittis, Riccardo Vella Refalo, Matthew |
| Keywords: | Aza compounds Amino acids -- Analysis Catalysts -- Environmental aspects Green chemistry Amberlyst-15 -- Analysis |
| Issue Date: | 2024 |
| Publisher: | MDPI AG |
| Citation: | Bosica, G., De Nittis, R., & Vella Refalo, M. (2024). DABCO/Amberlyst® 15-Cocatalysed One-Pot Three-Component Aza-Morita–Baylis–Hillman Reaction Under Green Conditions. Catalysts, 14(12), 873. |
| Abstract: | The one-pot multicomponent aza-Morita–Baylis–Hillman (MBH) reaction was performed under green conditions using 1,4-diazabicyclo[2.2.2]octane (DABCO) and Amberlyst® 15 as a co-catalyst, at ambient temperature and under negligible amounts of non-hazardous solvent. A number of α-methylene-β-amino acid derivatives were produced in good to excellent yields from different arylaldehydes, p-toluenesulfonamide and α,β-unsaturated carbonyl compounds. The environmental benignity of the process is accounted by the low E-factor (0.7) and high atom economy (95%) values obtained. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/129784 |
| Appears in Collections: | Scholarly Works - FacSciChe |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| DABCO Amberlyst 15 cocatalysed one pot three component aza Morita Baylis Hillman reaction under green conditions 2024.pdf | 1.99 MB | Adobe PDF | View/Open |
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