Incidence and survival of neuroendocrine neoplasia in the Maltese islands - a population-based study

Abstract

Introduction: The global incidence of neuroendocrine neoplasms (NENs) is increasing worldwide, however most studies are based on cancer-registry data, with different data collection methods, making it difficult for cross-country comparisons. Our study aims to analyze the incidence and survival of NENs in a well-defined population of the Maltese islands based on histological and radiological data.

Methods: A retrospective analysis of patients diagnosed histologically or radiologically with NEN at Mater Dei Hospital, the only central national service hospital in Malta, between 1st January 2015 and 31st December 2020, was performed. Detailed clinical, histopathological and radiological data was obtained. Patients were followed up till 31st December 2024 or death, whichever came first. Ageand sex-adjusted standardized incidence rates (SIRs), prevalence and mortality rates were calculated.