Editorial : rising stars in cellular neuropathology 2022

Abstract

We are grateful to all authors and reviewers for their outstanding contributions to this Research Topic. This compilation of original research articles aims to shed light on clinical and basic issues in cellular neuropathology, and provide the basis for potential therapeutic intervention. Vidal’s group presents two research articles on Degenerative Cervical Myelopathy (DCM). This involves spinal cord dysfunction from compression of the vertebral column around the neck region resulting from age-related changes that also cause pain, gastrointestinal dysfunction and severe neurological deficits. Using a mouse model of DCM, Farkas et al. illustrate the alterations of gut microbiota using 16S rRNA-based detection of bacterial groups from fecal samples in parallel to the altered response in immune cell composition by flow cytometry. The study reports that DCM may cause dimorphic gut dysbiosis with more pronounced effects in males. Specific bacterial families, such as Lachnospiraceae and Muribaculaceae, were significantly altered. These changes were linked to variations in microbe-derived metabolic products. This study highlights a reduction in butyrate-producing bacteria and a lesser impact on lactate-producing bacteria. Monitoring butyrate levels is valuable, yet detecting short-chain fatty acids in clinical settings remains challenging due to their volatility.