Nutraceuticals for cystic fibrosis : a new frontier in treatment

Abstract

Cystic Fibrosis (CF) is a genetic disorder that affects around 89,000 people worldwide. This condition arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which leads to impaired salt transport across cellular membranes. As a result, less water is transported through tissues, causing a thick, sticky mucus to accumulate in various parts of the body. This mucus build-up affects different organs, leading to a range of symptoms that significantly impact the quality of life and reduce life expectancy. For decades, treatment for cystic fibrosis has relied primarily on managing symptoms. However, recent advances in our understanding of biochemistry and nutrition have brought nutraceuticals into the spotlight as potential therapeutic aids. Nutraceuticals are natural compounds that may provide health benefits beyond basic nutrition. They offer hope for alleviating some of the burdens caused by CF and can serve as an adjunct to conventional treatment approaches. This article delves into the nature of CF, its impact on organ function, and the potential of certain nutraceuticals to help manage the condition.