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https://www.um.edu.mt/library/oar/handle/123456789/145888| Title: | Monocyte response to activated platelets : a transcriptional study |
| Authors: | Farrugia, Rosienne Gusnanto, A. Ellis, P. Langford, C. F. Goodall, A. H. Watkins, N. A. Ouwehand, W. H. |
| Keywords: | Monocytes Blood platelets Genomes Endotoxins |
| Issue Date: | 2007 |
| Publisher: | Elsevier BV |
| Citation: | Farrugia, R., Gusnanto, A., Ellis, P., Langford, C. F., Goodall, A. H., Watkins, N. A., & Ouwehand, W. H. (2007, July). Monocyte response to activated platelets : a transcriptional study. 21st Congress of the International Society of Thrombosis and Haemostasis, Switzerland. |
| Abstract: | Introduction: Plaque rupture exposes platelets to collagen resulting in their activation via the collagen-GPVI/FcRgamma signalling cascade. This signal is communicated to monocytes via two routes; directly by cell-cell contact, or indirectly by a wide spectrum of soluble factors in the platelet secretome. We used whole-genome expression arrays to define the changes in the monocyte transcriptome in response to CRP-18 (collagen-related peptide), a GPVI specific ligand, and contrasted this with the changes that occur upon activation by LPS (lipopolysaccharide) via the CD14/TLR4 signalling cascade. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/145888 |
| Appears in Collections: | Scholarly Works - FacHScABS |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Monocyte_response_to_activated_platelets_a_transcriptional_study_2007.pdf | 9.35 kB | Adobe PDF | View/Open |
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