Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/22593
Title: The 5-HT4 agonist prucalopride stimulates L-DOPA-induced dopamine release in restricted brain regions of the hemiparkinsonian rat in vivo
Authors: Navailles, Sylvia
Di Giovanni, Giuseppe
De Deurwaerdere, Philippe
Keywords: Dopamine
Levodopa
Rats as laboratory animals
Parkinson's disease
Issue Date: 2015
Publisher: Wiley-Blackwell Publishing Ltd.
Citation: Navailles, S., Di Giovanni, G., & De Deurwaerdère P. (2015). The 5-HT4 agonist prucalopride stimulates L-DOPA-induced dopamine release in restricted brain regions of the hemiparkinsonian rat in vivo. CNS Neuroscience & Therapeutics. 21(9), 745-747.
Abstract: The efficacy of L-3,4-dihydroxyphenylalanine (L-DOPA) in the treatment of Parkinson’s disease (PD) is impaired by anxiety or depression in some patients and iatrogenic side effects such as dyskinesia. Classical pharmacological tools such as selective serotonin reuptake inhibitors could be interesting to limit motor or nonmotor undesirable effects, but they directly target the activity of serotonergic neurons. Indeed, serotonergic (5-HT) neurons are responsible for L-DOPA-induced dopamine (DA) release and some of the inherent behavioral effects at the expense of 5-HT itself. Therefore, the difficulty emerging with the therapies associated with L-DOPA is to enhance central DA tone, without further alteration of 5-HT transmission and excessive striatal DA tone correlated to the possible appearance of dyskinesia.
URI: https://www.um.edu.mt/library/oar//handle/123456789/22593
Appears in Collections:Scholarly Works - FacM&SPB

Files in This Item:
File Description SizeFormat 
Navailles_et_al-2015-CNS_Neuroscience_&_Therapeutics.pdf
  Restricted Access
157.89 kBAdobe PDFView/Open Request a copy


Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.