Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/22595
Title: Central serotonin2C receptor : from physiology to pathology
Authors: Di Giovanni, Giuseppe
Matteo, Vincenzo di
Pierucci, Massimo
Benigno, Arcangelo
Esposito, Ennio
Keywords: Serotonin
Receptor, Serotonin, 5-HT
Depression, Mental
Schizophrenia
Receptor, Serotonin, 5-HT2C
Issue Date: 2006
Publisher: Bentham Science Publishers Ltd.
Citation: Di Giovanni, G., Di Matteo, V., Pierucci, M., Benigno, A., & Esposito, E. (2006). Central serotonin2C receptor : from physiology to pathology. Current Topics in Medicinal Chemistry, 6(18), 1909-1925.
Abstract: Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions. Although 5-HT is synthesized by a small group of neurons within the raphe nuclei of the brain stem, almost all parts of the CNS receive serotonergic projections. Furthermore, the importance of 5-HT modulation and the fine-tuning of its action is underlined by the large number of 5-HT binding sites found in the CNS. Hitherto, up to 15 different 5-HT receptors subtypes have been identified. This review was undertaken to summarize the work that has explored the pathophysiological role of one of these receptors, the 5-HT2C receptor, that has been emerged as a prominent central serotonin receptor subtype. The physiology, pharmacology and anatomical distribution of the 5-HT2C receptors in the CNS will be firstly reviewed. Finally, their potential involvement in the pathophysiology of depression, schizophrenia, Parkinson's disease and drug abuse will be also discussed.
URI: https://www.um.edu.mt/library/oar//handle/123456789/22595
Appears in Collections:Scholarly Works - FacM&SPB

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