Please use this identifier to cite or link to this item:
Title: Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat
Authors: Sardo, Pierangelo
Ferraro, Giuseppe
Di Giovanni, Giuseppe
Galati, Salvatore
La Grutta, Vittorio
Keywords: Basal ganglia
Nitric oxide
Rats as laboratory animals
Issue Date: 2002
Publisher: Elsevier Ireland Ltd.
Citation: Sardo, P., Ferraro, G., Di Giovanni, G., Galati , S., & La Grutta, V. (2002). Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat. Neuroscience Letters, 325(3), 179-182.
Abstract: The activity of single units in the striatum of urethane-anesthetized rats was recorded before and after the systemic administration of 7-nitro-indazole (7-NI; 50 mg/kg intraperitoneally), a selective inhibitor of neuronal nitric oxide (NO) synthase. Two neuronal types were clearly distinguishable electrophysiologically, on the basis of either discharge frequency pattern or features of the individual spike waveform (spike duration, negative phase/total duration ratio, and negative phase/total amplitude ratio). Only sporadically discharging neurons (basal firing rate, <0.1 spikes/s) were influenced by 7-NI, which caused a statistically significant increase in their firing rate. In contrast, the activity of continuously discharging neurons (basal firing rate, 4–6 spikes/s) was not affected. We hypothesize that NO neurotransmission could exert a tonic inhibitory influence upon sporadically discharging striatal neurons, which are presumably striatal output neurons.
Appears in Collections:Scholarly Works - FacM&SPB

Files in This Item:
File Description SizeFormat 
  Restricted Access
91.94 kBAdobe PDFView/Open Request a copy

Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.