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Title: High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo
Authors: Orban, Gergely
Pierucci, Massimo
Benigno, Arcangelo
Pessia, Mauro
Galati, Salvatore
Valentino, Mario
Muscat, Richard
Di Giovanni, Giuseppe
Keywords: Temporal lobe epilepsy
Dentate gyrus
Receptors, Serotonin
Depression, Mental
Issue Date: 2013
Publisher: Springer
Citation: Orban, G., Pierucci, M., Benigno, A., Pessia, M., Galati, S., Valentino, M., Muscat, R., & Di Giovanni, G. (2013). High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo. Experimental Brain Research, 230(4), 441-451.
Abstract: Although several studies have emphasized a crucial role for the serotonergic system in the control of hippocampal excitability, the role of serotonin (5-HT) and its receptors in normal and pathologic conditions, such as temporal lobe epilepsy (TLE), is still unclear. The present study was therefore designed firstly to investigate the acute effect of 8-OH-DPAT, a mixed 5-HT1A/7 receptor agonist, at a high dose (1 mg/kg, i.p.) known to have antiepileptic properties, in a model of acute partial epilepsy in rats. For this purpose, a maximal dentate activation (MDA) protocol was used to measure electrographic seizure onset and duration. In addition, the effect of 8-OH-DPAT on in vivo dentate gyrus cell reactivity and short- and long-term plasticity was studied. Rats injected with 8-OH-DPAT exhibited a significant reduction in MDA and epileptic discharges, a decrease in paired-pulse facilitation and an increase in long-term potentiation. This study suggests that 8-OH-DPAT or in general 5-HT1A/7 agonists might be useful for the treatment of TLE and also have some beneficial effects on the comorbid cognitive disorders seen in epileptic patients.
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