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Title: Assessment of neuronal and glial injury in a rodent model of focal ischemia
Authors: Vella, Jasmine
Zammit, Robert
Zammit, Christian
Muscat, Richard
Valentino, Mario
Keywords: Cerebrovascular disease -- Animal models
Cerebral ischemia -- Diagnosis
Neurovascular diseases -- Diagnosis
Issue Date: 2015
Publisher: Malta Medical School
Citation: Vella, J., Zammit, R., Zammit, C., Muscat, R., & Valentino, M. (2015). Assessment of neuronal and glial injury in a rodent model of focal ischemia. IX Malta Medical School Conference, St. Julian's.
Abstract: Human stroke affects equivalent volumes of gray and white matter. Traditionally, focus on assessment of ischemic injury in experimental models was dominated by histological assessment of neuronal viability and cell counts. However evidence has demonstrated the functional, behavioral and long-term impact of white matter lesions in stroke and therefore, a much needed effort to address the integrity of both gray and white matter lesions is important in devising strategies to protect the brain as a whole. Focal cerebral ischemia models simulating human stroke are indispensable in investigating cerebral gray and white matter injury. The intraluminal filament mouse middle cerebral artery occlusion (MCAO) model mimics one of the commonest causes of stroke in humans1 and is one of the most frequently used models in experimental stroke research. We adapt a mouse stroke model to study the pathological changes in the evolution of an infarct in both gray and white matter regions.
Appears in Collections:Scholarly Works - FacM&SAna
Scholarly Works - FacM&SPB

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