Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/26741
Title: A laser speckle contrast imaging system to study blood flow dynamics in the rodent brain
Authors: Zammit, Robert
Vella, Jasmine
Zammit, Christian
Muscat, Richard
Valentino, Mario
Keywords: Blood-vessels -- Physiology
Blood flow
Animal experimentation
Issue Date: 2015
Publisher: Malta Medical School
Citation: Zammit, R., Vella, J., Zammit, C., Muscat, R., & Valentino, M. (2015). A laser speckle contrast imaging system to study blood flow dynamics in the rodent brain. IX Malta Medical School Conference, St. Julian's.
Abstract: Optical imaging modalities have become increasingly prevalent in biomedical research for discerning functional and anatomical information. Laser Speckle Contrast Imaging (LSCI) is a non-invasive full-field optical imaging technique that gives a 2-D microcirculatory surface flow map within live tissue. LSCI is based on the grainy image produced by a laser light illuminating an object, known as a speckle pattern. The visual appearance of the speckle pattern produced by objects showing some kind of activity, such as flowing red blood cells (RBCs) is called a dynamic speckle. LSCI makes use of statistical analysis of the dynamic speckle pattern which is modulated by the speed information of the RBCs. The main setup of a LSCI consists of a 632 nm red laser, an optical imaging system and a CCD camera connected to a PC. LSCI is mainly used in pre-clinical studies by neuroscientists for CBF dynamics and in clinical examinations for blood perfusion imaging of the retina and the skin, for example during examination of burns.
URI: https://www.um.edu.mt/library/oar//handle/123456789/26741
Appears in Collections:Scholarly Works - FacM&SAna
Scholarly Works - FacM&SPB

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