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Title: Does quantitative heterogeneity of human fetal hemoglobin (Hb F) reveal friends or foes of KLF1 in globin gene switching?
Authors: Felice, Alex E.
Galdies, Ruth
Borg, Joseph
Grech, Godfrey
Cassar, Wilhelmina
Scerri, Christian A.
Patrinos, George P.
Philipsen, Sjaak
Keywords: Fetal hemoglobin
Issue Date: 2011
Publisher: The American Society of Hematology
Citation: Felice, A. E., Galdies, R., Borg, J., Grech, G., Cassar, W., Scerri, C. A.,...Philipsen, S. (2011). Does Quantitative Heterogeneity of Human Fetal Hemoglobin (Hb F) Reveal Friends or Foes of KLF1 in Globin Gene Switching?. Blood, 118:1092.
Abstract: The chemical heterogeneity of fetal hemoglobin (Hb F) due to variable ratios of the Gγ and Aγ globin subunits reflects genetic complexity because of common dimorphisms such as Hb F Sardegna (or Aγ75(E19) Ile>Thr; also known as AγT) in Caucasians, and common variants such the Gγ globin variant, Hb F Malta I (or Gγ117(G19) His>Arg) that is in tight linkage disequilibrium with the β globin variant Hb Valletta (or β87(F3) Thr>Pro) and is found in 1.8% of neonates from Malta.
Appears in Collections:Scholarly Works - FacM&SPB

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