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Title: | Does quantitative heterogeneity of human fetal hemoglobin (Hb F) reveal friends or foes of KLF1 in globin gene switching? |
Authors: | Felice, Alex Galdies, Ruth Borg, Joseph J. Grech, Godfrey Cassar, Wilhelmina Scerri, Christian A. Patrinos, George P. Philipsen, Sjaak |
Keywords: | Fetal hemoglobin |
Issue Date: | 2011 |
Publisher: | The American Society of Hematology |
Citation: | Felice, A. E., Galdies, R., Borg, J., Grech, G., Cassar, W., Scerri, C. A.,...Philipsen, S. (2011). Does Quantitative Heterogeneity of Human Fetal Hemoglobin (Hb F) Reveal Friends or Foes of KLF1 in Globin Gene Switching?. Blood, 118:1092. |
Abstract: | The chemical heterogeneity of fetal hemoglobin (Hb F) due to variable ratios of the Gγ and Aγ globin subunits reflects genetic complexity because of common dimorphisms such as Hb F Sardegna (or Aγ75(E19) Ile>Thr; also known as AγT) in Caucasians, and common variants such the Gγ globin variant, Hb F Malta I (or Gγ117(G19) His>Arg) that is in tight linkage disequilibrium with the β globin variant Hb Valletta (or β87(F3) Thr>Pro) and is found in 1.8% of neonates from Malta. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/28926 |
Appears in Collections: | Scholarly Works - FacHScABS Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Does_quantitative_heterogeneity_of_human_fetal_hemoglobin_(Hb_F)_reveal_friends_or_foes_of_KLF1_2011.pdf | 35.37 kB | Adobe PDF | View/Open |
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