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|Title:||One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions|
|Citation:||Bosica, G., & Zammit, R. (2018). One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions. PeerJ, 6(e5065), 1-29.|
|Abstract:||An environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of β-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component nitro-Mannich reaction between aldehydes, amines and nitroalkanes. The developed protocol is performed in a solvent-free medium to produce a variety of β-nitroamines in good to excellent yields within short reaction times. The catalyst can be easily prepared and recovered. It has been tested up to eight times with only a minor activity loss.|
|Appears in Collections:||Scholarly Works - FacSciChe|
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