Please use this identifier to cite or link to this item:
|Title:||Effects of SNPs in the COL1A1 and methylenetetrahydrofolate reductase genes on BMD in postmenopausal women in Malta|
Brincat, Mark P.
|Keywords:||Bone mineral density|
Genetic polymorphisms -- Malta
|Citation:||Balkan Journal of Medical Genetics. 2007, p. 9-18.|
|Abstract:||Two common single nucleotide polymorphisms (SNPs) within the COL1A1 gene and the C677T variant within the methylenetetrahydrofolate reductase (MTHFR) gene have been studied for correlation with bone mineral density (BMD) in 126 postmenopausal Maltese women (55.6 ± 7.1 years). All polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while BMD at the lumbar spine (LS), femoral neck (FN), Ward’s triangle and trochanter was measured by dual energy X-ray absorptiometry (DEXA). The observed genotype frequencies were similar to those in other populations and were in Hardy-Weinberg equilibrium. No association was observed between polymorphisms in the COL1A1 gene and BMD, even after adjustment for age, body mass index (BMI) and years since menopause. The Callele of the C677T variant of the MTHFR gene had a negative effect on trochanter BMD when testing for genetic models of dominant and recessive alleles (independent sample t-test: p = 0.03). Genotype frequencies of both genes did not differ significantly between normal women and those with a low BMD at either the LS or FN.|
|Appears in Collections:||Scholarly Works - FacHScABS|
Scholarly Works - FacM&SOG
Files in This Item:
|Angela Xuereb - EFFECTS OF SNPs IN THE COL1A1 AND.pdf||375.57 kB||Adobe PDF||View/Open|
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.