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Title: Development of a semi-preparative HPLC method for difluprednate
Authors: Sammut Bartolo, Nicolette
Zoidis, Grigoris
Vougogiannopoulou, N.
Ferrito, Victor
Serracino-Inglott, Anthony
Vella, J.
Keywords: Eye -- Surgery -- Treatment
Eye -- Inflammation -- Treatment
Steroid drugs
High performance liquid chromatography
Issue Date: 2016-04
Publisher: University of Malta. Department of Pharmacy
Citation: Sammut Bartolo, N., Zoidis, G., Vougogiannopoulou, N., Ferrito, V., Vella, J., & Serracino Inglott, A. (2016, April). Development of a semi-preparative HPLC method for difluprednate. Poster session presented at the 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, United Kingdom.
Abstract: A poster presentation regarding the development of a semi-preparative HPLC method for difluprednate. Introduction: In 2008, the steroid difluprednate was the first steroid to be approved by the Food and Drug Administration for the post surgery treatment of both pain and inflammation of the eyes.Synthesis often leads to the formation of impurities which may or may not be structurally similar to the desired product. This induces difficulties in purifying the product for instrumental analysis, for example NMR, in order to elucidate its structure. Purification of samples using semi-preparative HPLC provides a means to obtain highly pure samples in large enough amount to be used for further analysis. Aims: To develop a semi-preparative HPLC method for the separation and purification of difluprednate and impurities obtained during synthesis.
Appears in Collections:Scholarly Works - FacM&SPha

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