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Title: Analysis of amitriptyline and its metabolites
Authors: Mifsud Buhagiar, Luana
Sammut Bartolo, Nicolette
Vella Szijj, Janis
Ferrito, Victor
Serracino-Inglott, Anthony
LaFerla, Godfrey
Keywords: Amitriptyline -- Analysis
Metabolites -- Analysis
Chromatographic analysis -- Methodology
Cardiovascular toxicology
Issue Date: 2018-11
Publisher: University of Malta. Department of Pharmacy
Citation: Mifsud Buhagiar, L., Sammut Bartolo, N., Vella Szijj, J., Ferrito, V., Serracino Inglott, A., & LaFerla, G. (2018, November). Analysis of amitriptyline and its metabolites. Poster session presented at the X Malta Medical School Conference, St Julian's, Malta.
Abstract: A poster presentation regarding the analysis of amitriptyline and its metabolites. Aims: Amitriptyline, a tricyclic antidepressant, has been renowned for over half a century for its efficacy, pharmacoeconomic benefits and potential adverse effects. Most analytical procedures utilised for recommended therapeutic drug monitoring only account for amitriptyline as the parent drug and nortriptyline as the active demethylated metabolite. This project aimed to determine the hydroxylated metabolites which may prove expedient due to possible clinical effects, particularly cardiovascular toxicity.
Appears in Collections:Scholarly Works - FacM&SPha

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